Mitomycin

Mitomycin C, Azirino[2, 3:3, 4]Pyrrolo[1, 2-A]Indole-4, 7-Dione, 6-Amino-8-[[(Aminocarbonyl)Ox, Ametycine, Azirino(2, 3:3, 4)Pyrrolo(1, 2-A)Indole-4, 7-Dione, 6-Amino-1, 1A, 2, 8, 8A, 8B-Hexahy, Mitomycin


Generic

CAS No

50-07-7



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Mitomycin is a methylazirinopyrroloindoledione antineoplastic antibiotic isolated from the bacterium Streptomyces caespitosus and other Streptomyces bacterial species. Bioreduced mitomycin C generates oxygen radicals, alkylates DNA, and produces interstrand DNA cross-links, thereby inhibiting DNA synthesis. Preferentially toxic to hypoxic cells, mitomycin C also inhibits RNA and protein synthesis at high concentrations. (NCI04)

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